Figure 4 summarized SMARCA4-regulated genes. Interestingly, the downregulation of SMARCA4 resulted in DES and TNNT2 downregulation (Figure 4), which could further promote failure of heat, congestive heart failure and congestive heart disease based on the IPA-Tox analysis (Figure 3). Therefore, SMARCA4 is a promising upstream regulator candidate regulating multiple downstream genes contributing to heart failure-related phenotypes. The gene discussed is TNNT2; the disease is congestive heart failure.