Heresbach et al. [107], in their study to evaluate the severity of AP, found that levels of IL-1 predict severe AP on admission with a similar accuracy to IL-6 (82% versus 88%, respectively) and that IL-1 receptor antagonist had the best accuracy among different markers, including IL-6 and CRP, within the first 48 h. Here, CRP is linked to alkaline phosphatase measurement.