TRPM7 and breast cancer: In this study, we examined the role of TRPM7 channels in the proliferation, cytotoxicity, and apoptosis first in wild type HEK cells (WT-HEK) and a HEK293 cell line overexpressing TRPM7 (HEK-M7), and then in breast cancer cells, in which, for the first time, a novel TRPM7 knock-out MDA-MB-231 cell line is used.