To reveal whether the senescence induction in tumor cells is dependent on IFN-γ/TNF-α produced by IL-2/IL-12/IL-18-stimulated γδ T cells, we neutralized IFN-γ/TNF-α by anti-IFN-γ antibody or anti-TNF-α antibody or both antibodies. This evidence concerns the gene IL18 and neoplasm.