RNASE1 and infection: With this aim, first, we used the epithelial cells (Vero) from the monkey Cercopithecus aethiops (used as gold standard cells for infection assay) [32] to perform plaque assays (as described above) in the presence of small and large ZIKV C6/36 EVs (also RNase A + UV-treated and untreated samples).