At the endothelial vascular cell level, our data indicate that vascular ECs are susceptible to ZIKV activation and infection by C6/36 EVs, which favor the induction of tissue damage receptors, such as coagulation (TF) and inflammation (PAR-1) receptors, and adhesion molecule presence (ICAM-1) at the membrane surface level with an increase in cell permeability (Figure 12C). The gene discussed is ICAM1; the disease is infection.