ICAM1 and Zika virus infectious disease: At the endothelial vascular cell level, our data indicate that ECs are susceptible to ZIKV infection and activation by ZIKV C6/36 EVs, and these EVs favor the induction of damage receptors, such as coagulation (TF) and inflammation (PAR-1) receptors, and adhesion molecule (ICAM-1) presence at the cell membrane’s surface level (Figure 11).