Since leptin was produced by the adipose tissue, and that white adipose tissue (WAT), especially visceral WAT, plays an important role in the development of insulin resistance and glucose intolerance, we measured the weight and gene expression in adipose tissues at different locations of the body to evaluate whether the interaction of HF feeding and MCS on male offspring metabolism was mediated through metabolic changes in the adipose. This evidence concerns the gene LEP and hydrops fetalis.