Recently, Li et al. found that mitochondrial SIRT3 (sirtuin 3) is required for diffuse large B cell lymphomas (DLBCLs), but not normal germinal center B cells, to regulate glutamine flux to the tricarboxylic acid (TCA) cycle and acetyl-coenzyme A (CoA) pools [25]; this led to the development of the sirtuin inhibitor YC8-02, which is able to preferentially kill DLBCL cells. Here, SIRT3 is linked to diffuse large B-cell lymphoma.