Interestingly, members of the complex have been recently proposed as therapeutic targets in cancer such as COPA (coatomer protein complex subunit alpha) for mesothelioma, and COPB2 (coatomer protein complex subunit beta 2) for colorectal cancer, lung adenocarcinoma, cholangiocellular carcinoma, and gastric cancer [118,119,120,121,122,123]. This evidence concerns the gene COPA and cholangiocarcinoma.