Genes overexpressed in thyroid tumors include, among others, DUSP6 (dual specificity phosphatase 6) [62], CITED1 (cbp/P300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 1) [63], S100A11 (S100 calcium binding protein A11) [64], and TWIST1 (twist family BHLH transcription factor 1) [65]; their protumorigenic role has been assessed in preclinical models, showing that their inhibition reduces the thyroid tumor cell phenotype. This evidence concerns the gene TWIST1 and thyroid tumor.