In recent work, we investigated the anti-tumor efficacy of in vitro-generated CD103+ cDC1s, which resemble the migratory cDC1 subset found in vivo based on expression of canonical transcriptional regulators and cell surface markers, and efficient antigen cross-presentation to CD8+ T cells upon stimulation with polyinosinic-polycytidylic acid (poly I:C) [20]. The gene discussed is MPPE1; the disease is neoplasm.