To better understand the role of Mfn2 reduction in the brain areas affected in AD in adult mice, we bred the homozygous Mfn2fl/fl mice with CaMKIICreERT2 mice to generate Mfn2fl/fl/CAMKIICreER mice, which express Cre-recombinase driven by the CaMKII promoter in the forebrain neurons after treatment with tamoxifen. The gene discussed is MFN2; the disease is Alzheimer disease.