Nevertheless, although the association between neonatal leptinemia and childhood growth and adiposity (e.g., weight gain, BMI, and/or obesity) has been previously reported [48,49,50,51,52,53,54,55,56,57,58], the impacts of altered neonatal leptin levels on fat distribution during childhood still need to be clearly defined. Here, LEP is linked to obesity due to melanocortin 4 receptor deficiency.