Also based on ENCODE data, cg15758240 is in the vicinity of a number of transcription factor binding sites, including YY1 (−99 bp), CEBPB (−144 bp), USF1 (−164 bp), STAT3 (−184 bp), and GATA2 (−204 bp), which has been previously linked to obesity [36,37,38,39,40], suggesting that cg15758240 is located within a genomic region relevant for both fat accretion and transcriptional regulation activity. The gene discussed is STAT3; the disease is obesity due to melanocortin 4 receptor deficiency.