Previous studies have demonstrated that chemical inhibition of NGLY1 or p97—both of which are key players in the NRF1-mediated bounce-back response pathway—potentiated the apoptotic effect of proteasome inhibition in chronic myelogenous leukemia and cervical cancer cells [18] or multiple myeloma cells [24], respectively. The gene discussed is VCP; the disease is chronic myelogenous leukemia, BCR-ABL1 positive.