Additionally, Limtrakul et al. reported the effects of curcumin 38, demethoxycurcumin 39 and bisdemethoxycurcumin 40 (Figure 16) on the expressions of matrix metalloproteinases-2 (MMP-2), matrix metalloproteinases-9 (MMP-9), urokinase plasminogen activator (uPA), membrane Type 1 MMP (MT1-MMP), and tissue inhibitor of metalloproteinases (TIMP-2), in addition to in vitro invasiveness of human fibrosarcoma cells [45]. This evidence concerns the gene PLAU and fibrosarcoma.