The A/T genotype for FTO rs9939609 variant was more likely to be protective from the risk of T2DM when combined with either C/C for PPARγ rs1801282 and C/C for MC4R rs2229616 (OR = 0.25, p = 0.097) non-significantly or C/C for PPARγ rs1801282 and C/T MC4R rs2229616 (OR =0.04, p = 0.002, Table 6) significantly. The gene discussed is MC4R; the disease is type 2 diabetes mellitus.