Three studies evaluated the relationship between obesity and OA development via the inhibition of transient receptor potential cation channel, subfamily V, member 4 (TRPV-4), lecithin-cholesterol acyltransferase (Lcat), apolipoprotein A1 (Apoa1), and low-density lipoprotein receptor (Ldlr) in mice fed with a high-fat diet (60% kcal), Western-type diet (4.5 Kcal/g) or cholesterol-rich diet [109,110,111]. The gene discussed is APOA1; the disease is obesity due to melanocortin 4 receptor deficiency.