HIF1A and neoplasm: In brief, their results suggest that the simplest connection between these metabolic states can be represented by the levels of AMPK, HIF1α, and ROS, which lead tumor cells to face three different metabolic states: a Warburg state, characterized by high levels of pAMPK and low levels of HIF1α; an oxidative state, characterized by low levels of pAMPK and high levels of HIF1α; and an hybrid state, characterized by high levels of both pAMPK and HIF1α, ensured by high levels of ROS that stabilizes HIF1α and activates AMPK [82].