TRAP1 and neoplasm: In the mitochondria of tumor cells, TRAP1 is involved in a chaperone network that implies the formation of a ternary complex, together with HSP90 and the immunophilin cyclophilin D, that regulates the permeability transition pore opening, maintaining mitochondrial homeostasis, and antagonizing the proapoptotic function of cyclophilin D in permeability transition [70].