Moreover, built upon these evidences, and in light of the common biological functions of papillomavirus oncogenes [74], we may speculate that BPV oncoproteins could play a relevant role in regulation of HIF-1α pathway, contributing, at least in part, to the development of equine sarcoids by promoting HIF1α/VEGF mediated tumor angiogenesis. The gene discussed is VEGFA; the disease is neoplasm.