MAPT and Alzheimer disease: However, it has been demonstrated that aged 3xTg-AD mice, which carry insertions of mutant tau, human amyloid precursor protein (hAPP), and presenilin, displayed increased immobility time in the forced swim and tail suspension tests, measures of depression-like behavior in rodents during middle (10-month-old) [14] and older (18-month-old) [15] ages.