In view of the role PTGES-2 in obesity and in the control of intracellular cAMP concentrations through PGE2 receptors [30,32], we investigate the possible association between PTGES-2 and EPAC2 cAMP effector and ST2/IL-33 mechanosensitive genes. The gene discussed is RAPGEF4; the disease is obesity due to melanocortin 4 receptor deficiency.