Ginsenoside is able to increase the hair shaft length and hair existent time, which is similar to the action of MXD in in vivo experimental models (topical treatment in nude mice), moreover, it stimulates hair shaft elongation in ex vivo cultures of vibrissa HF and suppresses TGF-β-induced phosphorylation of ERK in HeLa cells [61]. This evidence concerns the gene TGFB1 and hydrops fetalis.