MAPT and Cerebral ischemia: Several years of intensive research have revealed that ischemic stroke and experimental cerebral ischemia are associated with numerous neuronal changes, including mitochondrial damage, synapse disappearance, β-amyloid peptide production and accumulation, microglia and astrocyte activation, tau protein phosphorylation, and neurofibrillary tangles formation [4,14,15,17,18,19,23,24].