MAPT and brain ischemia: Brain ischemia increases the permeability of the blood–brain barrier, which facilitates the invasion of inflammatory cells into the brain tissue and leakage of amyloid and tau protein from serum into the brain parenchyma, which in turn leads to progressive damage to white matter [15,20,21,40,41,42,43,44,45,46,47,48,49,50,51,52,53].