CD4 and cancer: To explore the potential effect of anti-androgen treatment on ARV7 and ARFL mRNA expression in PBMC we exposed a subpopulation (CD4 T-cells) from non-cancer controls to DHT or E. With the experimental conditions used, we showed that E significantly increased the expression of ARFL in one (25%) of the four controls (2.21-fold relative to E vehicle; P < 0.05) while non-significant changes were observed in ARV7 and ARFL expression with DHT or E treatment (Figure 3).