PMR1 also has an important role in embryogenesis [92], and pmr-1 mutants show important defects in cell migration and attachment that resemble the loss of skin cell adhesion observed in Hailey-Hailey disease, a dominant human disease caused by the loss of one of the copies of the SPCA1 gene [93]. This evidence concerns the gene ATP2C1 and Hailey-Hailey disease.