Fos-related antigen-1 (Fra-1), a Fos family protein involved in regulating cell proliferation, differentiation, and transformation by dimerizing with Jun family proteins to form AP-1, is highly expressed in human colon [5], breast [6], lung [7], esophagus [8], and bladder cancers [9]. The gene discussed is FOSL1; the disease is urinary bladder carcinoma.