Validation and characterization of the sesquiterpene plant metabolite by complementary methods revealed an unexpected TRPC3-selective, PLC- and diacylglycerol-independent mode of action that was confirmed in rat pheochromocytoma cells that endogenously express TRPC3 and TRPC6 [11]. Here, TRPC3 is linked to hereditary pheochromocytoma-paraganglioma.