Factors significantly associated with PFS according to the univariate Cox models were pNEN status (p = 0.012), tumor differentiation (p = 0.026), WHO grade G3 NEN/G3 NEC (p = 0.023), and Ki-67 proliferative rate > 20% (p = 0.013). The gene discussed is MKI67; the disease is neuroendocrine carcinoma.