However, the category of TSA can be expanded to include tumour specific glycosylation, such as TnMUC1 [31], tumour specific mutations in cell surface proteins, such as EGFRvIII [32] and misfolded proteins that escape refolding within the endoplasmic reticulum, such as misfolded-EGFR [33]. This evidence concerns the gene EGFR and neoplasm.