TNFRSF9 and glioblastoma: In glioblastoma, two clinical trials using EGFRvIII targeting CAR’s have recently been reported, the Novartis (scFv clone 2173) scFv is of second generation and designed with a CD137 costimulatory domain [26] and the NCI (scFv clone 139) CAR which incorporates a third generation signalling tail containing both CD28 and CD137 domains [19].