EGFR and colorectal carcinoma: Since CRC overexpresses epidermal growth factor receptors (EGFR)-transmembrane glycoproteins belonging to the tyrosine kinase receptor family [18], the aim of the current study was to enhance the delivery of 5-FU antineoplastic agents carried by AuNPs to target cells by coating them with anti-EGFR monoclonal drug antibodies.