YTHDF1 and neoplasm: In addition, there is definitely a need for further validation of these findings using in vivo experiments such as the use of mouse models harboring transgenic cassette with K5 promoter to target expression of sTAg to the epidermis (K5-sTAg-IRES-tdTomato) [31,32] or using YTHDF1lox/lox mouse models [33] to further investigate YTHDF1 role through m6A identification in tumor formation and progression.