ROMO1 and glioblastoma: Besides, when the expression of Romo1 in BMDMs (originated from the glioblastoma-bearing mice) was knocked down, the ROS level was significantly inhibited (Control shRNA vs. Romo1 shRNA, p<0.05, Figure 7D), and the M1 polarization was significantly promoted while the M2 polarization was inhibited (Control shRNA vs. Romo1 shRNA, p<0.05, Figure 7E).