In CD4+ T cells, CIT highlighted site-specific DNAm as a probable regulatory intermediate between risk variant-meQTLs and eQTMs at 5 risk loci (FDR < 0.05), implicating ANKRD55, JAZF1, ORMDL3, FCRL3, IL6ST, C11orf10, TAX1BP1, and GSDMB as genes with potential to confer perturbed immune function via this mechanism in RA. Here, ORMDL3 is linked to rheumatoid arthritis.