We validated cis-meQTL effects at 3 loci implicated by CIT (cg21124310/ANKRD55, cg07522171/JAZF1, and cg17134153/FCRL3) in an independent cohort of 39 patients with early arthritis using pyrosequencing (Fig 6, A-C). This evidence concerns the gene FCRL3 and arthritic joint disease.