For example, strong evidence is found for site-specific DNAm as an intermediary via which disease variants regulate ORMDL3, GSDMB, and JAZF1 expression by CD4+ T cells in RA, MS, and asthma, and a similar mechanism in relation to ANKRD55 and IL6ST is limited to RA and MS. This evidence concerns the gene ANKRD55 and rheumatoid arthritis.