CD4 and rheumatoid arthritis: Of the independent RA risk loci represented in our data sets (104 and 107 for CD4+ T and B cells, respectively), 24 exhibited cis-regulatory effects on DNAm in both cell types, with 8 identified uniquely in CD4+ T cells and 9 in B cells (Fig 2; see Table E6 in this article’s Online Repository at www.jacionline.org).