For e.g., the fold changes in MIP-3α with intra-amniotic infection and with sterile intra-amniotic inflammation were higher within vesicles compared to the soluble fraction of amniotic fluid (preterm labor with intra-amniotic infection vs preterm labor without either intra-amniotic inflammation or proven intra-amniotic infection: Δ log2 FC = 3.5; preterm labor with sterile intra-amniotic inflammation vs preterm labor without either intra-amniotic inflammation or proven intra-amniotic infection: Δ log2 FC = 1.4). The gene discussed is CCL20; the disease is chorioamnionitis.