ATP13A2 and parkinsonism due to ATP13A2 deficiency: One of the most interesting genes in the latter category is ATP13A2 (OMIM 610513), which was initially implicated in Kufor–Rakeb syndrome (KRS, OMIM 606693), characterized by early onset parkinsonism, pyramidal tract degeneration, dementia, and cognitive dysfunction (Ramirez et al., 2006).