CCNE1 and breast carcinoma: We also found that knocking out PRKD3 in the breast cancer cells led to the down‐regulation of the c‐MYC target genes such as VEGF, MTA1, PEG10 and hTERT (Figure 4A) and c‐MYC‐related genes such as CCND, CCNE and E2F (Figure S2).