Chen et al demonstrated that ESCO2 may be served as prognostic markers relying on its dysregulation in gastric cancer,20 lung squamous cell carcinoma,21 and melanomas.22 More interestingly, we gained the consistent results in RCC: through in vitro experiments, we found that ESCO2 knockdown significantly inhibited the proliferation, invasion and migration of RCC cells. Here, ESCO2 is linked to melanoma.