SMC3 and renal cell carcinoma: In addition, p53 has been reported as a major tumor suppressor, cooperating with the AKT/mTOR pathway.25, 26 The exertion of ESCO2 functions relied on the protein‐protein bindings, such as p53 and SMC3.20 Percival et al demonstrated that complete cohesion, abnormal chromosome segregation and genomic instability were induced by p53 and ESCO2 knockdown.27 Reduction of p53 in RCC cells transfected with si‐ESCO2 validated that there might have a correlation between ESCO2 and p53 in the development of RCC.