Establishment of cohesion 1 homolog 2 (ESCO2) is a member of Eco1 family, which contributes to sister chromatid cohesion (SCC) during cell cycle progression.4 It is well‐known that distinct statuses of cohesin are associated with different phases of cell cycle.5 Roberts syndrome (RBS) has ascertained correlation with the inactivation of ESCO2, which is caused by the SCC defects and fallacious transcription of acetylation.6, 7 Furthermore, SCC is responsible for DNA repair in cell proliferation.8 ESCO2 that holds the regulatory role is involved in the cohesion‐mediated DNA repair. This evidence concerns the gene SERPINB3 and Roberts-SC phocomelia syndrome.