Prior studies have noted the importance of AKT/mTOR pathway in RCC evolution, further, cohesion‐regulated by ESCO2 was associated with the AKT/mTOR signaling.23, 24 In accordance with that, we conducted Western blot to assess whether the AKT/mTOR signaling pathway is involved in the regulation of ESCO2 in RCC progression and the results concluded our hypothesis. The gene discussed is ESCO2; the disease is renal cell carcinoma.