ANG and Mental deterioration: Ang ‐ can cause CSVD, including vascular injury, neuroinflammation, and cognitive decline in mice.11, 12 The application of antihypertension drugs, such as inhibitors of the angiotensin receptor and angiotensin‐converting enzyme, failed to reverse neurological deficits such as cognitive impairment in CSVD patients.3, 13, 14 Alternative treatments for Ang ‐–induced CSVD need to be proposed.