The inhibition of SEMA4D/PlexinB1 signaling has been found to show clear therapeutic effects in multiple types of tumors (Evans et al, 2015), rheumatoid arthritis (Yoshida et al, 2015), multiple sclerosis (Smith et al, 2014), Huntington's disease (Southwell et al, 2015), and stroke (Zhou et al, 2018b) in preclinical studies. The gene discussed is SEMA4D; the disease is rheumatoid arthritis.