Compared to the gene expression profile of the Foxd1Cre::Pdgfrb+/J mice, patients with hypertensive diabetic and hypertensive nephropathies showed a similar and overlapping upregulation of 60.7 and 53.6% genes in glomeruli, and 85.7 and 64.2% of genes in the tubulointerstitium, respectively (Fig 8A). The gene discussed is PDGFRB; the disease is hypertensive nephropathy.