We next challenged the Foxd1Cre::Pdgfrb+/J mice with different models of kidney diseases targeting specific compartments, i.e., the unilateral ureteral obstruction (UUO) (Fig 7A and B), which induces a primary interstitial fibrosis without affecting the glomeruli, and angiotensin‐2‐infusion‐induced hypertensive nephropathy (Fig 7C–H), which mainly affects the glomeruli. The gene discussed is PDGFRB; the disease is hypertensive nephropathy.