The results showed that SNORA70B was positively related to CTNNB1 and USP34 was positively related to CTNNB1, MYC, TCF4 and TCF7L2, suggesting SNORA70B and its host gene USP34 might play significant roles in ccRCC tumorigenesis through ‘Wnt signalling pathway’. Here, TCF7L2 is linked to nonpapillary renal cell carcinoma.