RET and renal cell carcinoma: LRIG1 is known to encode a cell surface protein (leucine‐rich repeats and immunoglobulin‐like domains 1; LRIG1), which is known to negatively regulate epidermal growth factor receptor56 and ERBB‐family receptor degradation including RET and MET,57, 58 and deletions of LRIG1 occur somatically in RCC cases at a rate of 2.3% within the TCGA dataset,15 of which 94% were clear cell RCC.