Although this is consistent with the high frequency of 3p allele loss in sporadic clear cell RCC, the fundamental role of somatic inactivation of the VHL TSG in clear cell RCC and the incidence of somatic mutations of PBRM1, BAP1, and SETD2 in RCC, to date most RCC‐associated constitutional chromosome 3 rearrangements do not appear to disrupt known RCC TSGs mapping to 3p. This evidence concerns the gene VHL and renal cell carcinoma.