GS did not identify any plausible likely pathogenic or pathogenic SNVs or CNVs in previously reported inherited RCC genes (VHL, SDHB, SDHC, SDHD, MET, FLCN, FH, BAP1, and CDKN2B) in the four probands who were affected by RCC (the index case with the inv(3)(p21.1q12) had a family history of RCC but had not developed RCC). This evidence concerns the gene SDHD and renal cell carcinoma.