AGO2 and viral infectious disease: Furthermore, these results also suggested that CG7009 and CG5220K>A mutants failed to initiate or maintain a proper response to viral infection which, together with the results of the automiG, automiW and siRNA-activity reporter assays (Figures 1B and 2B, Supplementary Figure S1C), strongly supported that both gene products were required for efficient Ago2-dependent small interfering RNA-mediated silencing activities in Drosophila.