CFTR and intestinal obstruction: Tuggle et al generated a CFTR KO rat model by targeting exon 3 of Cftr with zinc‐finger endonuclease8 and reported phenotypes similar to those in humans, including growth defects, intestinal obstruction, abnormal dentition, agenesis of vas deferens, electrophysiological abnormalities and defects in the structure and mucus of the airways.