Downregulation of HNRNPK reduces p53 transcription, leading to DNA damage‐induced cell cycle arrest.11 In addition, HNRNPK can bind to the promoter region and to the 3′ untranslated region of p21 messenger ribonucleic acid (mRNA), which inhibits translation of p21 and increases translation initiation, cell division, and tumor formation.14, 15. The gene discussed is HNRNPK; the disease is neoplasm.