The first subtype is characterized by MYD88 and CD79B mutations (MCD) and is more frequent among ABC lymphomas; the second subtype is characterized by BCL6 fusions and NOTCH2 mutations (BN2) and is represented in similar proportions among ABC and GCB; the third is characterized by NOTCH1 mutations (N1), and is present more frequently among ABC the last subtype is characterized by EZH2 mutations and BCL2 translocations (EZB), and is present more frequently in GCB. This evidence concerns the gene BCL2 and lymphoma.