Double hit lymphomas (DHL) comprise approximately 10% of all DLBCL, with MYC/BCL2 being the more frequent subtype (65% of DHL cases), followed by MYC/BCL2/BCL6 triple hit (THL) lymphomas (20% of cases) and by MYC/BCL6 DHL (10% of cases).15–17 Most DHLs are of the GCB subtype. This evidence concerns the gene BCL2 and diffuse large B-cell lymphoma.