Of note, the single expression of MYC is present in 25% to 30% of lymphoma, irrespective of COO, and does not represent an adverse prognostic factor in patients treated with R-CHOP.23 In contrast, BCL2 overexpression is highly correlated with ABC subgroup, and in some series has been associated with inferior PFS, independently from international prognostic index (IPI) and COO.24 Here, BCL2 is linked to aneurysmal bone cyst.