A study by Wu et al found that polymorphisms in the GRIN1 and GRIN2B genes may serve as potential biomarkers for a reduced risk of PD among the Chinese population in Taiwan.31 Lee et al and Abidin et al found that polymorphisms in the GRIN2B gene were associated with an increased risk of developing impulse‐control behaviors among PD patients.32, 33 Therefore, genetic alteration in subunits of NMDARs do have involvement in the pathophysiology of PD. This evidence concerns the gene GRIN1 and Parkinson disease.