MUC16 and cancer: As for gene-level SM, the frequently muted genes for serous-like EC and OvCa both include TP53, MUC16, FLG and AHNAK. Notably, except TP53, almost all other mutated genes have frequencies less than 25%, suggesting that these two cancer types are belong to “copy number-driven” cancer (Ciriello et al., 2013).