TF and heart failure: Notably, iron polysaccharide had minimal effects on serum ferritin (median change from baseline of 18 ng/mL, 95% CI −8 to 38) and transferrin saturation (median change from baseline of 2%, 95% CI −3 to 7%).Figure 2 compares changes in serum ferritin and transferrin saturation between oral and intravenous iron repletion regimens in patients with heart failure at multiple time points.