Moreover, miR-144-3p was able to inhibit OSCC cell proliferation, migration and invasion in vitro as well as tumor growth in vivo. Additionally, we found that ERO1L is a direct target of miR-144-3p and miR-144-3p mediated downregulation of ERO1L resulted in a decrease in the activity of signal transducer and activator of transcription 3 (STAT3) in OSCC cells. This evidence concerns the gene ERO1A and neoplasm.