In previous studies, the ICIs combination strategies in first-line advanced NSCLC were anti-PD-1 with standard platinum-based chemotherapy in KEYNOTE-021, KEYNOTE-189, KEYNOTE-407, CHECKMATE-012 and CHECKMATE-227 trial, and anti-PD-L1 with standard platinum-based chemotherapy plus bevacizumab in IMpower150 and IMpower 131.19-22,24,27-29 These data has greatly encouraged researchers to combine ICIs with other regimens to maximize the efficacy of immunotherapy. The gene discussed is CD274; the disease is non-small cell lung carcinoma.