TP53 and cancer: As is shown in Table 4, the upregulated DEGs were mainly enriched in five pathways, that is, cell cycle (hsa04110), oocyte meiosis (hsa04114), cellular senescence (hsa04218), carbon metabolism (hsa01200), p53 signaling pathway (hsa04115).The downregulated DEGs were mainly enriched in five pathways, namely, EGFR tyrosine kinase inhibitor resistance (hsa01521), JAK-STAT signaling pathway (hsa04630), Calcium signaling pathway (hsa04020), Melanoma (hsa05218), MicroRNAs in cancer (hsa05206).