As TP53 was the top one mutated gene in high-UBE2C-expression(66% vs 16% in low-UBE2C-expression), it might play contributive role in the high level of UBE2C.KEGG pathway analysis of top 100 mutated genes in high-UBE2C- phenotype revealed they were mainly significantly enriched in endometrial cancer, human papillomavirus infection, thyroid hormone signaling pathway, colorectal cancer and small cell lung cancer. This evidence concerns the gene TG and colorectal cancer.