As TP53 was the top one mutated gene in high-UBE2C-expression(66% vs 16% in low-UBE2C-expression), it might play contributive role in the high level of UBE2C.KEGG pathway analysis of top 100 mutated genes in high-UBE2C- phenotype revealed they were mainly significantly enriched in endometrial cancer, human papillomavirus infection, thyroid hormone signaling pathway, colorectal cancer and small cell lung cancer. The gene discussed is TP53; the disease is human papilloma virus infection.