H441 NSCLC and K562 leukemia cells express on cell membrane high ADAM10 and low ADAM17 levels (22, Supplementary Fig. 1), and ADAM10 sheddase activity (ADAM10sa) is a dominant metalloproteinase (MP) activity of NSCLC and likely leukemia cells 22, 26. Here, ADAM17 is linked to leukemia.